The Wind River Range is not for nebbishes, and this glacier-framed, 40-mile round-trip hike up 13,804-foot Gannett, the state's tallest peak, is literally a high point. On five-day trips with Jackson Hole Mountain Guides ($1,495; jhmg.com), you'll leave Elkhart Park, 60 miles east of Jackson, as mules shoulder the load to the first campsite, then march through limber pines and granite monoliths and around glaciated lakes, camping at Island Lake and the snow-cradled Titcomb Basin. On summit day, get an early start to enjoy the top alone.