The domain of hardcore fishermen and duck hunters, with fewer than 13,000 visitors a year, this 19-mile-long barrier island is the remotest part of Cape Lookout National Seashore. Take the ferry ($75 per car, plus $14 per person) from the town of Atlantic, and ask the island caretaker to arrange drop-offs of bait and ice—the inlets teem with red drum and flounder. Rent one of 12 solar-powered cabins (from $110; ports­mouth­islandfish­ing.com) perched among the sea oats.